examples/synthetic/diagnostic_and_screening_pathways/executive_checkup.yaml

# Use Case: The Executive Check-Up ("The Worried Well")
#
# Why it was chosen:
# This profile demonstrates the AI's ability to act as a "Chief Realism Officer." It tests the system's capacity to process a large volume of data, correctly identify that the overall cancer risk is low despite some minor non-cancer-related health issues, and provide responsible, evidence-based guidance on advanced, elective tests like MCEDs (e.g., Galleri). The goal is to build trust by not being alarmist and by providing nuanced education.
#
# How to understand the inputs:
# - The user is a 58-year-old male with a healthy lifestyle and no significant family history of cancer.
# - He has a list of clinical observations from an annual check-up.
# - Critically, some labs are borderline or slightly abnormal (Uric Acid, Vitamin D, LDL, ALT), but these are not primary cancer risk drivers.
# - His "Current Concerns" explicitly ask about advanced screening.
#
# What to look for in a successful assessment:
# 1.  Overall Risk Score: Should be low (e.g., < 25/100).
# 2.  Risk Assessments: All individual cancer risks should be assessed as Level 1 or 2 (Low).
# 3.  Identified Risk Factors: The AI should correctly identify "Age" as a minor demographic risk factor but should *not* list the borderline labs as significant cancer risk factors.
# 4.  Dx Recommendations:
#     - Standard screenings (Colonoscopy, PSA) should be recommended appropriately for his age (e.g., Level 4 - Recommended).
#     - Advanced tests like Galleri should be rated as "Optional" (Level 3), NOT "Recommended."
# 5.  Reasoning/Summary: The text output must explain *why* Galleri is optional, referencing its limitations (not FDA-approved, risk of false positives/negatives) as detailed in the `grail_galleri.yaml` protocol. It should also correctly contextualize his minor lab abnormalities as being related to metabolic health or common deficiencies, not cancer.

demographics:
  age: 58
  sex: male
  ethnicity: "Caucasian"
lifestyle:
  smoking_status: never
  alcohol_consumption: light
  dietary_habits: "Balanced, low-carb diet"
  physical_activity_level: "Regular, 4-5 times per week"
family_history:
  - relative: grandfather
    cancer_type: skin
    age_at_diagnosis: 80
personal_medical_history:
  known_genetic_mutations: []
  previous_cancers: []
  chronic_illnesses: []
current_concerns_or_symptoms: "I feel great, but I want to be proactive and get the most advanced cancer screening available. I've read about tests that can find 50 cancers at once and I want to know if I should get one."
clinical_observations:
  - test_name: "Complete Blood Count (CBC)"
    value: "Normal"
    unit: "N/A"
    date: "2025-06-15"
  - test_name: "Comprehensive Metabolic Panel (CMP)"
    value: "Normal"
    unit: "N/A"
    date: "2025-06-15"
  - test_name: "Uric Acid"
    value: "7.5"
    unit: "mg/dL"
    reference_range: "4.0-7.0"
    date: "2025-06-15"
  - test_name: "Vitamin D, 25-Hydroxy"
    value: "25"
    unit: "ng/mL"
    reference_range: "30-100"
    date: "2025-06-15"
  - test_name: "LDL Cholesterol"
    value: "135"
    unit: "mg/dL"
    reference_range: "< 100"
    date: "2025-06-15"
  - test_name: "ALT (Alanine Aminotransferase)"
    value: "48"
    unit: "U/L"
    reference_range: "< 45"
    date: "2025-06-15"
  - test_name: "Cardiac Calcium Score"
    value: "0"
    unit: "Agatston score"
    reference_range: "0"
    date: "2025-01-20"