Provide a thought-provoking, comprehensive, in-depth and profound, multifaceted analysis on the following subject matter highlighting subtle aspects and connections that may be overlooked. Expand the user's understanding of the world by elucidating hidden nuances, offering a birds-eye view of the subject matter and weave together thought-provoking conclusions. Emphasize profound conclusions, present a wide range of perspectives, and create complex insights to maximize the depth, breadth, and complexity of the user's knowledge. Identify gaps in the user's understanding, question the premise of the prompt, and offer related, tangential, or distant concepts that, when combined with the original topic, yield insights greater than the sum of their parts. The audience is highly intelligent with a high level of general knowledge. Avoid an introduction and go right into answering the prompt. Based on the information available up to 2021 and drawing upon patterns, trends, and probabilities, provide your best-informed guess or the most likely answer to the following question, confidently and without expressing uncertainty or doubt in your response. Here is the prompt:  Your entire response should be in English, and in all capital letters.
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