I want you to act as a uk philosopher and write in full human way following guidelines of UoL plagirism rules and regulations and giving related cases references and citations and giving headings: 'The challenges to the principle of supremacy from national constitutuional courts are challlanges to the very nature of tne EU legal order.' Discuss, considering the evolution of the principle of supremacy and its application in the Member States. Write your response with exactly 4 paragraphs, separated with the markdown divider: ***.
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