Read this abstract and discussion section from a paper and then answer the questions.

Please answer these questions with a single sentence each:
* What is the most important takeaway from the study?
* How is the study novel compared to previous work?
* What could be the greatest critique to challenge the conclusions?

ABSTRACT
To examine the possible non-specific effects (NSEs) of the novel COVID-19 vaccines, we reviewed
the randomised control trials (RCTs) of mRNA and adenovirus-vector COVID-19 vaccines
reporting overall mortality, including COVID-19 deaths, accident deaths, cardiovascular deaths
and other non-COVID-19 deaths. For overall mortality, with 74,193 participants and 61 deaths
(mRNA:31; placebo:30), the relative risk (RR) for the two mRNA vaccines compared with placebo
was 1.03 (95% CI=0.63-1.71). In the adenovirus-vector vaccines there were 122,164 participants
and 46 deaths (vaccine:16; controls:30). The RR for adenovirus-vector vaccines versus
placebo/control vaccine was 0.37 (0.19-0.70). The adenovirus-vector vaccines were associated
with protection against COVID-19 deaths (RR=0.11 (0.02-0.87)) and non-accident, non-COVID-19
deaths (RR=0.38 (0.17-0.88)). The two types of vaccines differed significantly with respect to
impact on overall mortality (p=0.030) as well as non-accident, non-COVID-19 deaths (p=0.046).
The placebo controlled RCTs of COVID-19 vaccines were halted rapidly due to clear effects on
COVID-19 infections. However, the data presented here argue for performing RCTs of mRNA and
adeno-vectored vaccines head-to-head comparing long-term effects on overall mortality.

DISCUSSION
Based on the RCTs with the longest possible follow-up, mRNA vaccines had no effect on overall
mortality despite protecting against fatal COVID-19. On the other hand, the adenovirus-vector
vaccines were associated with lower overall mortality and lower non-accident, non-COVID-19
mortality. The pattern of effects was internally consistent in the RCTs of mRNA and adenovirusvector vaccines, respectively.
An intrinsic limitation for the estimation of overall mortality during the COVID-19 pandemic is
the nature of the cohorts studied. Most of the volunteers participating in the trials were adult
individuals in general good health, resulting in low COVID-19 and overall mortality. In a real-life
situation in which the COVID-19 vaccines are administered to highly vulnerable populations with
high COVID-19-dependent mortality, significant gains in overall mortality are expected, also for
mRNA vaccines. However, the intriguin Write your response using less than 800 words.
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