I got the comments: 2.	It makes sense to show the long-term models linearly, but for comparisons across the time windows, it would be really nice to also provide estimates for the same dichotomous exposure cut offs as the 4- and 8-week exposures.  I reply: However, the observed exposure-response function between annual average temperature and epigenetic age acceleration markers was linear. Therefore, applying a non-linear model as used for the 4-week and 8-week exposures would be inappropriate. The most rigorous approach is to use the model type (linear vs. non-linear) that best fits the observed exposure-response function for each time window. In this study, we applied non-linear distributed lag models for the 4-week and 8-week exposures due to their non-linear functions, and a linear model for the annual average given its linear relationship. Therefore, while comparing effects for same models seems intuitively appealing, applying this approach would not be grounded in the actual data and may lead to spurious findings. The current analysis, which utilizes the most appropriate model is likely more robust.  But my supervise: But if your association is linear and you know the effects per 1°Ci increase, then you would also be able to calculate the effect size if temperature increases from the median temperature to the 97.5th percentile and also reversely the effect size if temperature decreases from median to 2.5th percentile, you just need to use the difference in temperature between the median and these percentiles and use that as an increment instead of 1°C. Then at least we have a similar way to show the effects….on the other hand, one needs to say that, of course the percentiles of a 4- or 8-week average mean something else than the percentiles of an annual average. So maybe we just do this in the answer of the review and for the latter reason say that we do not include it in the manuscript? 
What do the others think about this?      Provide your response in exactly 6 paragraphs (separated nearby paragraphs with 3 aterisk symbols ***).
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