Please polish the following text using the tone of the discussion of a Cell paper: 'This study has some limitations that must be addressed in future work. 

First, the classification of wavefront ENCCs was based primarily on their transcriptomic profiles and their spatiotemporal distribution. The transcriptional differences between these putative wavefront ENCCs and other bipotent ENCCs were relatively subtle, suggesting that wavefront ENCCs gradually change into their more specified progenies, rather than abruptly switch their fate. Therefore, our classification scheme may not precisely represent the transient states of bipotent ENCCs. Although we identified a large set of differentially expressed genes and validated several with immunostaining, a more extensive analysis of other markers is needed to confirm the identity and properties of wavefront ENCCs. Functional studies are also required to determine whether the identified genes are critical regulators of ENCC proliferation, migration and differentiation.

Second, findings regarding cell-cell interaction proteins, transcription factors and signaling pathways during ENCC migration and differentiation were solely based on transcriptomic data. Further work is needed to validate these findings at the protein level in both mice and humans. Experimental manipulations of the identified genes and pathways will be necessary to conclusively demonstrate their functional importance in ENCC development.

Finally, while our spatial transcriptional data suggest that the arrival of wavefront ENCCs triggers sequential gene expression in the developing gut, this remains a correlative finding. The causal relationship between gene expression and the arrival of wavefront ENCCs should be examined using Ednrb-/- mutant mice.' Provide two versions of response separated with exactly 6 asterisk symbols: ******.
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