Question: An investigator suspects that acetaminophen use during the first trimester of pregnancy can cause neural tube defects. She estimates the risk of neural tube defect in the general population is 1:1,000. Which of the following is the best study design to investigate the hypothesis?
A: Cohort study
B: Case-control study
C: Clinical trial
D: Ecologic Study
Please eliminate two incorrect options first, then think it step by step and choose the most proper one option. There should be exactly 3 paragraphs separated by the markdown divider: ***.
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