
Draw up a strategic game plan as to how to respond to the reviewers based on the following response: Reviewer #1 (Comments to the Author (Required)):

In this review, NAME_1 et summarize age-related changes in the extracellular matrix (ECM) that might contribute to age-related diseases and mortality. The topic is very interesting and I can only fully agree that the ECM has been largely neglected in the field of aging research and it is time to publish a summary like this. The manuscript is well-written, easy to read and contains a lot of information.
I understand that it is almost impossible to cover all age-related ECM changes in the many different tissues of the body and, in particular, also in the numerous components of the ECM. However, it remains a bit unclear on what basis the ECM glycoproteins that are discussed in more detail have been selected. Even though mansucript is not a clssical systematic review, the authors might want to explain how they searched for relevant literature.
I like the whole concept and how it is depicted in Figure 1. The information is complex and the authors do not (and can not) claim copmleteness. However, I think there are a couple of minor things that the authors might want to consider (in the Figure and accordingly also in the text). In the diagnostics part, one could include electron miscrocopy to detect amorphous collagen deposition. Further, the posttranslational changes could be categorized in more chemical methods (1,5,6) and more functional test (2, 3 ,4). Many ECM bioma In your entire response, the letter k should appear less than 28.
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