Given the abstract, objectives and selection criteria should the study be included or excluded? Give your answer as Included or Excluded only. Abstract: Three attenuated Salmonella typhi strains have been constructed by introducing deletions in aroC and aroD or deletions in cya and crp into one of two wild type parent strains, Ty2 or ISP1820. These mutant strains were designated CVD 906 ISP1820 delta aroC delta aroD, CVD 908 Ty2 delta aroC delta aroD, and chi 3927 Ty2 delta cya delta crp. Two studies were conducted with 36 healthy adult inpatient volunteers to determine in a double blind fashion the safety and immunogenicity of approximately 5 x 10 4 and 5 x 10 5 CFU of each of these three vaccine candidates given as a single dose. No statistically significant difference in the incidence of reactions among vaccinees was observed. Fever oral temperature greater than or equal to 38. 2 degrees C occurred in 2 of 12 volunteers who received CVD 906, in 0 of 12 who received CVD 908, and in 1 of 12 who received chi 3927. Vaccine bacteremia without symptoms occurred in 1 of 12 vaccinees who received CVD 906, in 0 of 12 who received CVD 908, and in 2 of 12 who received chi 3927. Overall, 19 53 of 36 vaccinees developed immunoglobulin G antibody to S. typhi lipopolysaccharide after vaccination, with no statistically significant differences in the rate of seroconversion among volunteers in the three groups. We conclude that defined mutations in the aromatic biosynthetic pathway and in the cyclic AMP global regulatory system attenuate S. typhi. Mutant strains CVD 906, CVD 908, and chi 3927 are highly and approximately equally immunogenic but possibly differ in their propensity to induce fever. Further studies are needed to document the apparent relative safety of CVD 908 as a typhoid vaccine and as a vaccine carrier of foreign antigens. \n Objectives: To assess the effects of vaccines for preventing typhoid fever. \n Selection Criteria: Randomized and quasi randomized controlled trials RCTs comparing typhoid fever vaccines with other typhoid fever vaccines or with an inactive agent placebo or vaccine for a different disease in adults and children. Human challenge studies were not eligible. Please answer in JSON format.
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