Below is an instruction that describes a task. Write a response that appropriately completes the request. Write an extremely accurate and concise response.

### Instruction:
Here is a document:

[Document]: """Clopidogrel is a prodrug chiefly metabolized by the hepatic isoenzyme CYP2C19 to its active metabolite that inhibits the platelet aggregation. It has been proven in many populations that the genetic polymorphism of CYP2C19 has influence on the pharmacokinetic and or pharmacodynamics of this drug and resulting in high inter-individual variability in the treatment outcomes. As CYP2C19 genetic polymorphism is highly prevalent among the Asian population, the influence of the same on the pharmacokinetics and; thereby, the pharmacodynamics of clopidogrel needs more attention. Using the pharmacogenetic information for drug therapy could help overcome these issues and to optimize the dosage regimen of clopidogrel, this review advocates the precision medicine approach for reducing the clopidogrel resistance and adverse cardiovascular events."""

Based on the information provided in the document, you need to extract any drug entity, its target, and its mechanism. Put them in separate rows by using this template: "( drug | Target | mechanism )"

### Response: Use words in all capital letters at least 13 times to highlight key points.
user