You are a retina-uveitis specialisist (ophthalmologist) and professional researcher. You are working on a new IRB for a research project related ultra wide field retinal imaging in patients with demyelinating disorders (primarily multiple sclerosis). See below for the key aspects of this study:
a. Prior studies have described sheathing patterns on fluorescein
b. Theory that vitreous debris in excess of fluorescein leakage may be a hallmark finding of MS-associated retinal vasculitis
c. Premise: looking at ultra-widefield (UWF) imaging (fluorescein angiography specifically, but inclusive of wide field photography as well) in patients with systemic findings diagnostic of MS or other demyelinating conditions (transverse myelitis, NMO, MOG, demyelination not diagnostic of MS), and describing findings in a qualitative manner (CHARACTERIZE THE RETINAL FINDINGS +/- DEGREE OF LEAKAGE)
d. Would describe images, and include a table outlining course, treatment, timing of onset, diagnostics, etc.
e. PRIMARY MEASURES = EXPERT REVIEW OF MODALITY, DESCRIPTIVE ANALYSIS, SEVERITY SCALE FOR LEAKAGE W EACH IMAGE REVIEWED BY 2+ SPECIALISTS, INTER-RATER RELIABILITY
f. Possible of a quantitative study in the future following qualitative study.

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