перевести на русский Collection of blood from small laboratory animals is necessary for a wide range of scientific research and there are a number of efficient methods available for that. It is important that blood sample collection from experimental animals should be least stressful because stress will affect the outcome of the study. Various regulatory agencies and guidelines have restricted the use of animals and the techniques used for blood collection in laboratory animals. This article deals with the approved blood collection techniques for laboratory animals like rodents, lagomorphs and nonrodents. Permission of the Institute Animal Ethics Committee has been obtained for the use of animals for demonstrating the techniques.

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GENERAL PRINCIPLES OF BLOOD COLLECTION IN ANIMALS
The method of blood collection should be described in the protocol approved by the Institute animal ethics committee.
It should be least painful and stressful. Blood sample may be collected under anesthesia [Table 1] or without anesthesia.[1]
Table 1
Commonly recommended anesthetic agents for laboratory animal experiments

Animal species	Short anesthesia	Medium anesthesia	Long anesthesia
Mice	Isoflurane (inhalation)	Xylazine + ketamine	Xylazine + ketamine
Halothane (inhalation)	(5 mg + 100 mg i.m.)	(16 mg+60 mg i.m./i.p.)
Xylazine + ketamine	Xylazine + ketamine
(5 mg + 100 mg i.m.)	(16 mg +60 mg i.m./ i.p.) or
Urethane (1200 mg/kg i.p.)
Guinea pig	Isoflurane (inhalation)	Xylazine + ketamine	Xylazine + ketamine
(2 mg + 80 mg i.m. There should be exactly 4 paragraphs separated by the markdown divider: ***.
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