Document:  Combining chemotherapy with immunotherapy still remains a regimen in anticancer therapy. Novel 4-thiazolidinone-bearing hybrid molecules possess well-documented anticancer activity, and together with anti-HER2 antibodies, may represent a promising strategy in treating patients with gastric cancer with confirmed human epidermal growth factor receptor 2 (HER2) expression. The aim of the study was to synthesize a new 4-thiazolidinone derivative (Les-4367) and investigate its molecular mechanism of action in combination with trastuzumab or pertuzumab in human AGS gastric cancer cells. AGS cell viability and antiproliferative potential were examined. The effect of the tested combinations as well as monotherapy on apoptosis and autophagy was also determined. Metalloproteinase-2 (MMP-2), intercellular adhesion molecule 1 (ICAM-1), pro-inflammatory and anti-inflammatory cytokine concentrations were also demonstrated by the ELISA technique.

Based on the information provided in the document, you need to extract every drug entity, its target, and its mechanism from the document. Show the results as triplets of entities following this format (drug entity | target entity| mechanism entity). Be extremely precise, and concise, and follow the triplet specified format! Your answer should have exactly 10 paragraphs. Make sure that the 5th paragraph starts with the word "action" and that each paragraph is separated by two new lines.
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