please rewrite the following text using the tone of the discussion of a Cell paper. Please keep all the information and add more information if necessary: 'While the intestinal microenvironment regulates ENS development, previous reports have shown that ENCCs in turn can modulate the local extracellular matrix environment. For example, ENCDCs produce tenascin-C (TNC), an ECM protein that promotes ENCDC migration during ENS development (NAME_1 et NAME_2., 2013; NAME_3 and NAME_4, 2006a; Newgreen et NAME_2., 1980). ENCDCs also secrete matrix metalloproteases (MMPs) and Collagen 18 that remodel the gut ECM (NAME_5 et NAME_2., 2016; NAME_3 2018). Not only modifying the ECM, our study revealed that wavefront ENCCs causes a broad gene expression change in other intestinal cells. Our spatial transcriptomics study reveals how ENCCs orchestrate the sequential activation of gene expression in different cell types in the gut wall. At the leading edge of the migratory wavefront, genes involved in signal transduction, mesenchymal cell differentiation and Wnt signaling pathway are enriched, suggesting that the arrival of wavefront ENCCs modifies the gut cells microenvironments for ENCC colonization and migration. One of the examples is Sfrp1, which encodes a secreted protein that inhibits Wnt signaling, was enriched in the distal region, where only very few ENCCs colonized. This implies that Sfrp1-mediated Wnt signaling may play an important role in regulating ENCC migration. While at the segment where the trailing ENCC locate, more genes related to neuronal development and extracellular matrix structural constituent are expressed. One of the examples is the Asb4 gene, which is a member of the ankyrin repeat and SOCS box–containing family of proteins, which acts as a substrate-recognition module to mediate the polyubiquitination and subsequent degradation of substrate proteins. It contains an ankyrin repeat region where specific protein–protein interactions occur and a SOCS box region which serves as a generic adapter directing the degradation of proteins targeted by the ankyrin repeat region. ' Write exactly 7 paragraphs each separated with two new lines answering this question. The last paragraph must start with "guarantee".
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