change to perfect tense: We want to express our gratitude for taking the time to evaluate our manuscript, which focuses on the changes in the extracellular matrix (ECM) that occur with aging. Your feedback is greatly appreciated, particularly your positive comments on the significance of the topic and the clarity of our writing. We concur with your suggestion that the ECM has received insufficient attention in aging research, and we are pleased that our manuscript has contributed to highlighting its importance.
 Give two different versions of responses. Please separate the responses with 6 asterisk symbols: ******.
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