Below is an instruction that describes a task. Write a response that appropriately completes the request. Write an extremely accurate and concise response.

### Instruction:
Here is a document:

[Document]: """The effect of the tested combinations, as well as monotherapy on apoptosis and autophagy, was also determined. Metalloproteinase-2 (MMP-2), intercellular adhesion molecule 1 (ICAM-1), pro-inflammatory and anti-inflammatory cytokine concentrations were also demonstrated by the ELISA technique. We proved that pertuzumab and trastuzumab were very effective in increasing the sensitivity of AGS gastric cancer cells to novel Les-4367. The molecular mechanism of action of the tested combination is connected with the induction of apoptosis. Additionally, the anticancer activity is not associated with the autophagy process. Decreased concentrations of pro-inflammatory
cytokines, MMP-2, and ICAM-1 were observed. The novel combination of drugs based on anti-HER2 antibodies with Les-4367 is a promising strategy against AGS gastric cancer cells. """

Based on the information provided in the document, you need to extract any drug entity, its target, and its mechanism. Put them in separate rows by using this template: "( drug | Target | mechanism )"

### Response: The response should be in all capital letters.
user