Question: An investigator suspects that acetaminophen use during the first trimester of pregnancy can cause neural tube defects. She estimates the risk of neural tube defect in the general population is 1:1,000. Which of the following is the best study design to investigate the hypothesis?
A: Cohort study
B: Case-control study
C: Clinical trial
D: Ecologic Study
Please eliminate two incorrect options first, then think it step by step and choose the most proper one option. First repeat the request without change, then give your answer.
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