Use example between the two “&” as a guide to format your response, be sure the hierarchical outline has indents and line breaks and reduces the word count 50-75% while omitting as few details as possible. Follow the example closely to explain how to understand “Your Vignette” and reach the correct answer.  & Example Question: “A 6-year-old boy is brought to your office for a routine check-up. His mother remarks that he often seems uninterested in playing with his peers and appears to run out of breath quickly. His medical records reveal that he has missed several pediatric vaccinations and has been hospitalized twice, once with a ‘chest infection’ and once with abdominal pain. The patient mentions to you that occasionally his ‘bones hurt.’ Which of the following protein changes most likely accounts for this patient’s condition?”  I. Example Restated Question: 6yo boy, routine check-up. Uninterested in play, dyspnea on exertion, missed vaccines, 2 prior hospitalizations for chest infection and abdominal pain, bone pain. Which protein change accounts for the patients condition?  II. Example Answer: NAME_1 substitution for Lysine  III. Example To reach answer, you must understand: Sickle Cell Anemia is caused by V6E (hydrophobic → hydrophilic) pt mutation in the beta globin gene → formation of HbS (polymerizes at low O2 tension) → sickling, hemolysis, and occlusion”   IV. Ruled Out: include info from vignette before the question mark that is included go specifically rule out a diagnosis.    V. Example Most sugges The letter g should appear at least 49 times.
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