public static void main(final String[] args) throws Exception {
        final PoolingAsyncClientConnectionManager cm = PoolingAsyncClientConnectionManagerBuilder.create()
                .setConnectionConfigResolver(route -> {
                    // Use different settings for all secure (TLS) connections
                    if (route.isSecure()) {
                        return ConnectionConfig.custom()
                                .setConnectTimeout(Timeout.ofMinutes(2))
                                .setSocketTimeout(Timeout.ofMinutes(2))
                                .setValidateAfterInactivity(TimeValue.ofMinutes(1))
                                .setTimeToLive(TimeValue.ofHours(1))
                                .build();
                    }
                    return ConnectionConfig.custom()
                            .setConnectTimeout(Timeout.ofMinutes(1))
                            .setSocketTimeout(Timeout.ofMinutes(1))
                            .setValidateAfterInactivity(TimeValue.ofSeconds(15))
                            .setTimeToLive(TimeValue.ofMinutes(15))
                            .build();
                })
                .setTlsConfigResolver(host -> {
                    // Use different settings for specific hosts
                    if (host.getSchemeName().equalsIgnoreCase("httpbin.org")) {
                        return TlsConfig.custom()
                                .setSupportedProtocols(TLS.V_1_3)
                                .setHandshakeTimeout(Timeout.ofSeconds(10))
                                .build();
                    }
                    return TlsConfig.DEFAULT;
                })
                .build();
        try (final CloseableHttpAsyncClient client = HttpAsyncClients.custom()
                .setConnectionManager(cm)
                .build()) {

            client.start();

            for (final URIScheme uriScheme : URIScheme.values()) {
                final SimpleHttpRequest request = SimpleRequestBuilder.get()
                        .setHttpHost(new HttpHost(uriScheme.id, "httpbin.org"))
                        .setPath("/headers")
                        .build();

                System.out.println("Executing request " + request);
                final Future<SimpleHttpResponse> future = client.execute(
                        SimpleRequestProducer.create(request),
                        SimpleResponseConsumer.create(),
                        new FutureCallback<SimpleHttpResponse>() {

                            @Override
                            public void completed(final SimpleHttpResponse response) {
                                System.out.println(request + "->" + new StatusLine(response));
                                System.out.println(response.getBody());
                            }

                            @Override
                            public void failed(final Exception ex) {
                                System.out.println(request + "->" + ex);
                            }

                            @Override
                            public void cancelled() {
                                System.out.println(request + " cancelled");
                            }

                        });
                future.get();
            }

            System.out.println("Shutting down");
            client.close(CloseMode.GRACEFUL);
        }
    }
This example demonstrates how to use connection configuration on a per-route or a per-host
basis.
httpclient5/src/test/java/org/apache/hc/client5/http/examples/AsyncClientConnectionConfig.java